2,4-Dichloropyrimidine: A Key Intermediate in Pharmaceutical and Agrochemical Synthesis

In the realm of organic and medicinal chemistry, certain compounds stand out due to their versatility and wide-ranging applications. One such compound is 2,4-Dichloropyrimidine, a chlorinated heterocyclic compound used extensively as a building block in pharmaceutical, agrochemical, and fine chemical industries. Its unique structure and reactivity make it a crucial intermediate in the synthesis of various high-value molecules. This blog provides a detailed yet easy-to-understand overview of 2,4-Dichloropyrimidine, its properties, applications, and significance in industrial chemistry.

What is 2,4-Dichloropyrimidine?

2-4 dichloropyrimidine is a heterocyclic compound derived from pyrimidine, substituted with chlorine atoms at the 2nd and 4th positions of the ring. Pyrimidine is an important nitrogen-containing ring system found in nucleic acids like DNA and RNA, and its derivatives are widely used in medicinal chemistry.

• Chemical Formula: C₄H₂Cl₂N₂

• Molecular Weight: 148.98 g/mol

• CAS Number: 3934-20-1

• Appearance: White to off-white crystalline powder

• Boiling Point: Approximately 203–205°C

• Melting Point: 58–61°C

Its dual chlorine substitution enhances its reactivity, making it a valuable starting material in chemical synthesis.

Properties of 2,4-Dichloropyrimidine

• Reactivity: The electron-deficient nature of the pyrimidine ring and the presence of chlorine atoms at reactive positions make this compound highly suitable for nucleophilic substitution reactions.

• Solubility: It shows good solubility in organic solvents like dichloromethane, acetone, and ethanol.

• Stability: It is stable under standard storage conditions and can be handled safely with standard laboratory precautions.

These chemical features are key to its use as a versatile intermediate in organic transformations.

Applications of 2,4-Dichloropyrimidine

The primary value of 2,4-Dichloropyrimidine lies in its role as a precursor for synthesizing more complex molecules across various sectors:

1. Pharmaceutical Industry

• It is frequently used in the synthesis of antiviral, anticancer, and antimicrobial agents.

• The chlorinated pyrimidine ring serves as a core structure in many active pharmaceutical ingredients (APIs).

• 2,4-Dichloropyrimidine acts as a key intermediate in the preparation of pyrimidine-based kinase inhibitors, commonly used in cancer treatment.

2. Agrochemical Industry

• It is employed in the manufacture of herbicides, fungicides, and pesticides.

• The compound contributes to the design of molecules that target specific biochemical pathways in plants and pests.

3. Specialty and Fine Chemicals

• It is used in the preparation of customized organic compounds in research and development settings.

• Its reactivity allows for easy substitution with various functional groups, enabling tailored compound synthesis.

4. Research and Development

• Chemists utilize 2,4-Dichloropyrimidine in structure-activity relationship (SAR) studies for drug development.

• It serves as a base for synthesizing analogs and exploring new pharmacological properties.

Manufacturing and Quality at LifeChem Pharma

At LifeChem Pharma, we manufacture and supply high-purity 2,4-Dichloropyrimidine suitable for industrial and laboratory applications. Our product is known for:

• Consistent purity levels exceeding 98%, ensuring reliability in synthesis.

• Batch-to-batch uniformity with rigorous quality control protocols.

• Compliance with global regulatory and safety standards.

• Custom packaging solutions to suit various volume requirements.

We supply this compound to global clients in the pharmaceutical, biotech, and agrochemical sectors, supporting both small-scale R&D and bulk production.

Storage and Handling

Proper storage and handling ensure the longevity and performance of 2,4-Dichloropyrimidine:

• Storage Conditions: Store in a cool, dry, and well-ventilated area away from heat and moisture.

• Handling Precautions: Use protective gloves, goggles, and clothing. Avoid inhalation or direct contact.

• Disposal: Dispose of contents and containers in accordance with local environmental regulations.

Following these guidelines helps maintain the integrity of the compound and ensures safety in usage.

Why Choose LifeChem Pharma for 2,4-Dichloropyrimidine?

• Reliable Supply Chain: We maintain ready stock to ensure timely delivery.

• Technical Expertise: Our team supports clients with documentation, COAs, MSDS, and application advice.

• Global Reach: We ship to customers in multiple countries with strict adherence to quality and compliance.

• Customer Focused: Flexible order sizes and prompt response to client queries.

Conclusion

2,4-Dichloropyrimidine is more than just a chemical compound—it's a vital tool in the synthesis of many life-enhancing products, from medicines to agricultural solutions. Its versatility, reactivity, and structural importance make it a go-to intermediate for chemists worldwide. At LifeChem Pharma, we are proud to supply premium-grade 2,4-Dichloropyrimidine to meet the evolving needs of the chemical industry. We are a trusted Methyl vinyl ketone supplier, offering high-purity products for industrial and research applications.